Epitalon Reviews

References

Twenty citations: the published primary literature on Epitalon.

Primary literature

The references below are numbered to match inline citations across all pages of this site. Entries are listed in order of first citation. Authors, journal, year, DOI, and PubMed or PMC URL are given for each entry. Where a DOI was not available in the published abstract, that field is noted.

  1. Khavinson VK, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bulletin of Experimental Biology and Medicine. 2003;135(6):590-592. ↗
  2. Al-dulaimi A, Thomas E, Matta H, Roberts T. Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. Biogerontology. 2025. ↗
  3. Anisimov VN, Khavinson VK, Popovich IG, Zabezhinski MA, Alimova IN, Rosenfeld SV, et al. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003;4(4):193-202. ↗
  4. Anisimov VN, Khavinson VK, Alimova IN, et al. Epithalon Decelerates Aging and Suppresses Development of Breast Adenocarcinomas in Transgenic HER-2/neu Mice. Bulletin of Experimental Biology and Medicine. 2002;134(2):187-190. ↗
  5. Khavinson VK, Izmaylov DM, Obukhova LK, Malinin VV. Effect of epitalon on the lifespan increase in Drosophila melanogaster. Mechanisms of Ageing and Development. 2000;120(1-3):141-149. ↗
  6. Anisimov VN, Khavinson VK, Popovich IG, Zabezhinski MA. Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats. Cancer Letters. 2002;183(1):1-8. ↗
  7. Kossoy G, Anisimov VN, Ben-Hur H, Kossoy N, Zusman I. Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice. In Vivo. 2006;20(2):253-257. ↗
  8. Anisimov VN, Popovich IG, Zabezhinski MA, Rozenfeld SV, Khavinson VK, Semenchenko AV, Yashin AI. Effect of epitalon and melatonin on life span and spontaneous carcinogenesis in senescence accelerated mice (SAM). Voprosy Onkologii. 2005;51(1):93-98. ↗
  9. Khavinson V, Diomede F, Mironova E, Linkova N, Trofimova S, Trubiani O, Caputi S, Sinjari B. AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism. Molecules. 2020;25(3):609. ↗
  10. Sinjari B, et al. Short Peptides Protect Oral Stem Cells from Ageing. Stem Cell Reviews and Reports. 2020;16(3):598-608. ↗
  11. Khavinson V, Goncharova N, Lapin B. Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys. Neuroendocrinology Letters. 2001;22(4):251-254. ↗
  12. Khavinson V, Razumovsky M, Trofimova S, Grigorian R, Razumovskaya A. Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa. Neuroendocrinology Letters. 2002;23(4):365-368. ↗
  13. Araj SK, Brzezik J, Madra-Gackowska K, Szeleszczuk L. Overview of Epitalon—Highly Bioactive Pineal Tetrapeptide with Promising Properties. International Journal of Molecular Sciences. 2025;26(6):2691. ↗
  14. Anisimov VN, Khavinson VK, et al. Effect of synthetic thymic and pineal peptides on biomarkers of ageing, survival and spontaneous tumour incidence in female CBA mice. Mechanisms of Ageing and Development. 2001;122(1):41-68. ↗
  15. Khavinson VK, Linkova NS, Ivko OM, et al. AEDG Peptide Regulation of the Expression of Human Circadian Rhythm Genes upon Accelerated Aging of the Pineal Gland. Advances in Gerontology. 2021;11(1):37-43. ↗
  16. Anisimov VN, Khavinson VK, Popovich IG, Zabezhinski MA, Alimova IN, Rosenfeld SV, et al. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003;4(4):193-202. [Antimutagenic data — same study as citation 3; cited separately for chromosomal aberration and SAMP/SAMR strain data]. ↗
  17. Araj SK, Brzezik J, Madra-Gackowska K, Szeleszczuk L. Overview of Epitalon—Highly Bioactive Pineal Tetrapeptide with Promising Properties. International Journal of Molecular Sciences. 2025;26(6):2691. [Pinealocyte AANAT/pCREB data — same review as citation 13; cited separately for melatonin-pathway section]. ↗
  18. Khavinson VK, Izmaylov DM, Obukhova LK, Malinin VV. Effect of epitalon on the lifespan increase in Drosophila melanogaster. Mechanisms of Ageing and Development. 2000;120(1-3):141-149. [Epithalamin comparison data — same paper as citation 5]. ↗
  19. Gatta M, Dovizio M, Milillo C, Ruggieri AG, Sallese M, Antonucci I, Trofimov A, Khavinson V, Trofimova S, Bruno A, Ballerini P. The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy. Stem Cell Reviews and Reports. 2025. ↗
  20. Epitalon-activated telomerase enhance bovine oocyte maturation rate and post-thawed embryo development. Livestock Science. 2025. ↗
  21. Khavinson VKh, Morozov VG. Peptides of pineal gland and thymus prolong human life. Neuroendocrinology Letters. 2003;24(3-4):233-240. ↗